A resource for healthcare professionals caring for patients with Cushing’s syndrome
Calling all endocrinologists: the 2025 Cushing’s Hub Competition starts now!
The Editorial Board is delighted to announce the 2025 Cushing’s Hub Competition, in which endocrinologists worldwide are invited to submit a clinical case scenario for inclusion in the Cushing’s Hub Interactive Case Studies series.
If you have first-hand experience of a clinical case scenario that may be of interest to the global medical community, the Cushing’s Hub team would love to hear from you!
To learn more about the competition – and potentially see your clinical case scenario promoted throughout Europe and beyond – click below.
Basics of Cushing’s Syndrome
Cushing’s syndrome is a rare disease resulting from chronic exposure to excessive circulating levels of cortisol produced from tumours in the pituitary or adrenal glands or from other sources.
This introductory section on Cushing’s Hub is designed for non-specialists who may be largely unfamiliar with the disorder, such as medical students, GPs, or specialists from other fields. Here you will find an explanation of the symptoms of Cushing’s syndrome in adults together with a detailed description of the pathophysiology and its resultant impact on morbidity and mortality.
Congratulations to the Winner of the 2025 Cushing’s Hub Competition
The Editorial Board is again delighted to congratulate Dr Stefano Testa of the Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy, winner of the 2025 Cushing’s Hub Competition, whose outstanding Interactive Clinical Case is now available to view online.
Dr Testa’s case emphasises the importance of considering extra‑adrenal sources of cortisol excess in unexplained ACTH‑independent disease and highlights the crucial role of histopathology and immunohistochemistry in determining tumour origin and malignancy status. The case study also illustrates the need for a structured multidisciplinary approach in managing complex endocrine oncology cases.
To explore some of the challenges associated with less common disease presentations, click here.
FEATURED
2023 Cushing’s Hub Competition winning Interactive Clinical Case now available!
The Cushing’s Hub Editorial Board is delighted to announce the release of the webcast from the second event in the Cushing’s Hub Webinar Series – Explore Real-World Clinical Scenarios in Mild Autonomous Cortisol Secretion (MACS) – held on Tuesday 24 October.
Chaired by Dr Susan M. Webb, Barcelona, Spain, this webcast sees panelists Assoc. Prof. Iacopo Chiodini, Milan, Italy and Dr Irina Bancos, Rochester, MN, USA, discuss, using a case-centred approach, the clinical management of low-grade excessive cortisol secretion and take questions from the audience.
Latest from across Cushing's Hub
Experts, patients, and advocates gathered in Barcelona for the 2nd Cushing’s Syndrome Awareness Day Conference—an event that not only deepened understanding of the lasting neurocognitive and emotional burden of the disease but also marked a major milestone: the launch of Spain’s first national Cushing’s patient association (ANPC). Discover how this meeting is shaping a more holistic, patient-centred future for Cushing’s care.
Combining ubiquitin specific peptidase 8 genotype with tumor size could help predict the risk for recurrence in patients with Cushing’s disease who have undergone successful pituitary surgery, say researchers.