Matthias Kroiss and colleagues outline the clinical characteristics, treatment, and outcomes of patients with the rare condition of ectopic Cushing’s syndrome associated with advanced medullary thyroid cancer.

GIP-dependent primary bilateral macronodular adrenal hyperplasia with Cushing’s syndrome is caused by aberrant expression of the GIP receptor in adrenal lesions. This multicentre, retrospective, cohort study at endocrine hospitals and university hospitals in France, Canada, Italy, Greece, Belgium, and the Netherlands aims to identify the underlying genetic driver event.

Maria Fleseriu and colleagues from 13 countries across five continents have developed updated consensus recommendations for the diagnosis and management of Cushing’s disease, which were published online in The Lancet Diabetes & Endocrinology in October 2021.