Publication Highlights

Cyclic Cushing's syndrome presents with phases of hypercortisolism (peaks) and physiological cortisol secretion (troughs). This Publication Highlight summarizes a systematic review of 118 articles set up to identify common features to help physicians avoid misdiagnoses or missed diagnoses.

Differentiating between neoplastic and nonneoplastic hypercortisolaemia can be challenging. This Publication Highlight summarises work by Findling and Raff on the likelihood of cortisol excess having a neoplastic or nonneoplastic origin.

The impact of Cushing’s syndrome on mental health is well known, with psychiatric symptoms frequently persisting following remission of Cushing’s syndrome. But do all psychiatric symptoms similarly remain, and over what period? This Publication Highlight describes the work of Bengtsson D, et al. whose findings emphasize both the need for early diagnosis of Cushing’s syndrome and continual mental health monitoring.

The use of radiotherapy in the treatment of pituitary adenoma or craniopharyngioma is associated with risk of second brain tumour, although its quantitative assessment has traditionally been hampered by methodological limitations. This Publication Highlight describes the work of Hamblin R, et al. whose retrospective cohort study helps clarify the risks associated with irradiation.

The European Reference Network on Rare Endocrine Conditions surveyed the prevention of venous thromboembolism in Cushing’s syndrome patients in European reference centers. Read the Publication Highlight to see the results reported by van Haalen et al. on behalf of the Endo-ERN Cushing and Thrombosis Study Group.

This retrospective cohort study from four European referral centres examined data from the patient records of individuals with ectopic Cushing’s syndrome induced by medullary thyroid cancer. Read the Publication Highlight to see what Koehler et al. and the German Study Group for Rare Malignant Tumours of the Thyroid and Parathyroid Glands discovered.